Michael L. LaCroix-Fralish
Clinical Assistant Professor
Dr. LaCroix-Fralish is a member of the didactic faculty of the Physician Assistant Program at Marist. Prior to joining Marist, Dr. LaCroix-Fralish spent over 14 years engaging in translational biomedical research in industry. Dr. LaCroix-Fralish was previously Vice President, Aging Biology at Cellular Longevity, a geroscience focused biotech company. Prior to that, Dr. LaCroix-Fralish was Director of Neuroscience Research at Regeneron Pharmaceuticals, where he led the development of Regeneron’s monoclonal antibody therapeutics for the treatment of sensory and neurodegenerative disorders. While at Regeneron, Dr. LaCroix-Fralish also launched a multidisciplinary Biology of Aging research group and led its nascent scientific strategy. His team at Regeneron advanced multiple candidate molecules into clinical development. Dr. LaCroix-Fralish is a graduate of Minnesota State University, Mankato, where he holds a B.S. in Biology. He holds a Ph.D. in Pharmacology (Neuroscience) from Dartmouth College. He was awarded an Alan Edwards Foundation postdoctoral fellowship to conduct neurogenetics research with Professor Jeffrey Mogil at McGill University where he identified novel genetic associations for interindividual differences in sensory perception in mouse and humans. He has authored 25+ papers published in peer-reviewed journals and is an inventor on 17+ patents.
PhD, Pharmacology and Toxicology, Dartmouth College, 2006
BS, Biology:Toxicology, Minnesota State University, Mankato, 2002
Research Interests/Areas of Focus
Physiology and Pharmacology
Neuroscience (sensory and neurodegenerative disorders)
Aging and Gerontology
Silverberg JI, Simpson EL, Guttman-Yassky E, Cork M, de Bruin-Weller M, Yosipovitch G, Eckert L, Chen Z, Ardeleanu M, Shumel B, LaCroix-Fralish ML, Hultsch T, Rossi AB,Hamilton JD, Orengo JM, Ruddy M, Graham NMH,Pirozzi G,Gadkari A. (2019) Dupilumab Significantly Modulates Pain and Discomfort in Patients with Atopic Dermatitis. JAMA Dermatology
Atanasio A, Decman V, White D, Ramos M, Ikiz B, Lee H-C, Siao C-J, Brydges S, LaRosa E, Bai Y, Fury W, Burfeind P, Zamfirova R, Warshaw G, Orengo J, Oyejide A, Fralish M, Auerbach W, Poueymirou W, Freudenberg J, Gong G, Zambrowicz B, Valenzuela D, Yancopoulos G, Murphy A, Thurston G, and Lai KM (2016). C9orf72 ablation causes immune dysregulation characterized by leukocyte expansion, autoantibody production, and glomerulonephropathy in mice.Nature Scientific Reports. Mar 16;6:23204.
Mogil JS, Sorge RE, LaCroix-Fralish ML, Smith SB, Fortin A, Sotocinal SG, Ritchie J,Austin JS, Schorscher-Petcu A,Melmed K, Bittong RA, Mokris JB, Neubert JK, Campbell CM, Edwards RR, Haithornthwaite J, Campbell JN, Crawley JN, Lariviere WR, Sternberg WF, Belfer I, Balaban CD, and Fillingim RB (2011). Vasopressin analgesia in mice and humans is mediated by a gene-environment interaction involving the AVPR1A gene and acute stress.Nat Neurosci. 14(12):1569-73.
Langford DJ, Bailey AL, Chanda ML, Clarke SE, Drummond TE, Echols S, Glick S, Ingrao J, Klassen-Ross T, LaCroix-Fralish ML, Matsumiya L, Sotocinal SG, Tabaka J, Wong D,. van den Maagdenberg A, Ferrari MD, Craig KD, Mogil JS (2010). Coding of facial expressions of pain in the laboratory mouse. Nature Methods. 7(6):447-449.
LaCroix-Fralish ML, Mo G, Smith SB, Sotocinal SG,Ritchie J,Austin JS, Melmed K, Schorscher-Petcu A, Laferriere AC, Lee TH,Romanovsky D, Liao G, Behlke MA, Clark DJ, Peltz G, Séguéla P, Dobretsov M, Mogil JS (2009).The beta3 Subunit of the Na+,K+-ATPase Affects Pain Sensitivity. Pain. 144(3):294-302.
Rice AS, Cimino-Brown D, Eisenach JC, Kontinen VK, Lacroix-Fralish ML, Machin I; Preclinical Pain Consortium, Mogil JS, Stöhr T (2008).Animal models and the prediction of efficacy in clinical trials of analgesic drugs: a critical appraisal and call for uniform reporting standards.Pain. 139(2):243-247.
LaCroix-Fralish ML, Tawfik VL, Spratt KF, DeLeo JA (2006). Sex differences in lumbar spinal cord gene expression following experimental lumbar radiculopathy. Journal of Molecular Neuroscience. 30(3):283-296.
LaCroix-Fralish ML, Tawfik VL, Tanga FY, Spratt KF, DeLeo JA (2006). Differential spinal cord gene expression in rodent models of radicular and neuropathic pain. Anesthesiology. 104(6):1283-1292.
Awards and Honors
Distinguished Young Alumni award, Minnesota State University, Mankato
Alan Edwards Foundation fellow
Albert J. Ryan Foundation fellow